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KMID : 0043320070300091055
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Archives of Pharmacal Research
2007 Volume.30 No. 9 p.1055 ~ p.1061
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Synthesis and Biological Activity of 5-{4-[2-(Methyl-p-substituted phenylamino)ethoxy] benzyl}thiazolidine-2,4-diones
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Gim Hyo-Jin
Kang Bo-Mi
Jeon Raok
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Abstract
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Thiazolidinedione derivatives are potential antidiabetic drugs that bind and activate peroxisome proliferator activated receptor γ (PPARγ), which is a member of the nuclear hormone receptor superfamily and enhances insulin sensitivity. In an effort to develop a novel and effective thiazolidindione derivative, 5-{4-[2-(methyl-p-substituted phenylamino)ethoxy]benzyl}thiazolidine- 2,4-diones 7 have been prepared by Mitsunobu reaction of the hydrophobic segment, methyl-p-substituted phenylaminoethanol 4 with hydroxybenzylthiazolidinedione 5 and their ability to activate PPARγ and inhibit LPS-induced NO production were evaluated
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KEYWORD
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Thiazolidinedione, PPARγ, Nitric oxide, Diabetes, Inflammation
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